Molecular determinants of response to anti-programmed cell death (PD)-1 and anti-programmed death-ligand 1 (PD-L1) blockade in patients with non-small-cell lung cancer profiled with targeted next-generation sequencing. Molecular analysis of circulating tumor cells identifies distinct copy-number profiles in patients with chemosensitive and chemorefractory small-cell lung cancer. Pembrolizumab in patients with extensive-stage small-cell lung cancer: results from the phase Ib KEYNOTE-028 study. Tumor mutational burden and response rate to PD-1 inhibition. Phase II study of maintenance pembrolizumab in patients with extensive-stage small cell lung cancer (SCLC). Tumor mutational burden (TMB) as a biomarker of response to immunotherapy in small cell lung cancer. Tumor mutational burden and efficacy of nivolumab monotherapy and in combination with ipilimumab in small-cell lung cancer. PD-L1 expression in small cell neuroendocrine carcinomas. Nivolumab alone and nivolumab plus ipilimumab in recurrent small-cell lung cancer (CheckMate 032): a multicentre, open-label, phase 1/2 trial. Signatures of mutational processes in human cancer. First-line atezolizumab plus chemotherapy in extensive-stage small-cell lung cancer. Developing new, rational therapies for recalcitrant small cell lung cancer. In this Review, we describe the available data on clinical efficacy, the emerging evidence regarding biomarkers and ongoing clinical trials using ICIs and other immunotherapies in patients with SCLC.īernhardt, E. After three decades, ICIs have finally enabled an improvement in OS for patients with SCLC however, a substantial amount of research remains to be done, including identifying the optimal therapeutic strategy and predictive biomarkers. Tumour mutational burden might have some predictive value, although blood-based measures of tumour mutational burden did not have predictive value in patients receiving atezolizumab plus chemotherapy in the first-line setting. PD-L1 expression is typically low or absent in SCLC, which has precluded its use as a predictive biomarker. Substantial research interest exists in identifying predictive biomarkers that could guide the use of ICIs in patients with SCLC. In patients with relapsed disease, data from nonrandomized trials have revealed promising responses, although a significant improvement in OS over that obtained with conventional chemotherapy was not achieved in a randomized trial in this setting. In the first-line setting, the addition of the anti-programmed cell death 1 ligand 1 (PD-L1) antibody atezolizumab to chemotherapy improves overall survival (OS). Immune-checkpoint inhibitors (ICIs) are approved in the first-line and third-line settings for patients with extensive-stage or relapsed small-cell lung cancer (SCLC), respectively.
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This can be done by deconstructing desert torches into hardened pearlsand blocks and torches with the shimmer liquid found in the Aether cave biome. With the 1.4.4 Labor of Love update, it is possible to create an artificial Hallow biome in pre-hardmode.However, the Pearlstone present can still produce small fragments of Hallow biome, which can show pink water and enrage Plantera. Due to the Jungle being mostly Mud, this can lead to there not being enough Hallow blocks present to consistently spawn the biome's enemies. Again, on beginning Hardmode the Hallow can overlay the Jungle, and this will convert stone but not Jungle grass.Based on the source code, the Dryad considers the Hallow to be "good", as opposed to the Corruption or Crimson, which she considers "bad." However, she does not consider the world to be "pure" until all three are eradicated.The Hallow will sometimes not spawn on the Surface only underground.The Hallow can spread to Grass and Flower Walls.The Corruption or Crimson is unable to overlap the Hallow.However, oddly, Lightning Bugs will still spawn during night.Making an artificial Hallow biome in a pre-Hardmode world (for example via Blue Solution) will change the background and music, though no Hallow enemies will spawn. In Hardmode, all enemies in the Hallow have a chance of dropping a Hallowed Key.An artificial Hallow biome requires at least 125 / 100 Hallowed blocks, such as Hallowed grass, Pearlstone, Pearlsand, or Pink Ice.Although their color is different, Cacti still drop Cactus when cut, and Waterleaf plants are also able to grow.įor more information, see NPC happiness. It is very similar to the Hallow: the music theme is the same, the enemies are the same (except for the Light Mummy and Crystal Thresher), and the background is slightly different. When the Hallow spreads through desert, it becomes Hallowed Desert. If Hallow is introduced into a pre-Hardmode world, its spread will be very limited, similarly to the evil biomes. This can result in areas where the Hallow and an evil biome intertwine closely. Hallow can convert Crimson and Corruption into grass blocks, but otherwise cannot convert blocks already claimed by an evil biome. Defeating Plantera for the first time reduces the speed of the Hallow's spread by 50*1/2 (50%). This means that it slowly converts certain susceptible tiles that are in the vicinity of existing Hallowed blocks. The Hallow spreads itself, similar to the evil biomes. The Dryad can tell the player the percentage of Hallow and Corruption/Crimson in the world. The Hallow, unlike Crimson and Corruption, cannot spread through mud areas such as those found in Jungles or Glowing Mushroom biomes. See below or the Biome spread page for more details. Hallow can also be seeded in new areas via Hallowed Seeds, Holy Water, or Blue Solution. Once generated, Hallow spreads in a manner similar to the evil biomes Pearlstone, Pearlsand, and dirt blocks growing Hallowed grass will spread Hallow to neighboring blocks, causing Hallow enemies to spawn over ever-larger areas. If areas of Jungle or Glowing Mushroom biome are included in the conversion area, Stone Block will be converted but the (mud based) grasses will be unaffected. This biome can replace preexisting sections of the world's " evil biome" ( Corruption or Crimson). It is generated along with a large Underground Hallow biome upon beating the Wall of Flesh and entering Hardmode. The Hallow does not exist in newly-generated worlds. The Underground Hallow biome can be found directly beneath a naturally-generated Hallow biome. It is characterized by pastel-colored fairytale graphics, with colorful cyan-colored grass, multicolored trees, and a large rainbow in the background, as well as similarly whimsical-looking (though dangerous) enemies. I can help you with painting that if you want. Happy with choice, happy with website user experience, happy with checkout, happy with delivery, happy with price!Once you enter hallowed land, you will see a rainbow in the sky. Delivered prompt in good environmentally friendly packaging, very neat, perfect condition. Actually googled it to see if it was legit! Took a punt, and there you have it, bought most of Christmas. I'm a bit green, I knew I didn't want to experience the big toy superstore, and honestly never heard of Toy Street. I had never come across Magic Market, for example, popular in France apparently. What I especially love is those unique meaningful toys aren't just shoved at the back, they are everywhere! Rather than just towering shelves of identikit brands that main competitors offer, there is genuine choice. Toy Street is so refreshing, the choice really seems to have some thought behind it. Galactic War causes game to crash on certain planets (PA:Titans) Discussion in Support started by angelmolina, July 23, 2020. The default location for minidumps generated by PA is now the logs directory in the Planetary Annihilation data directory. Forums > Planetary Annihilation Games > Planetary Annihilation: TITANS > Support >. Sounds like the server executable is is the. Finder > option key + Go menu > Library: crashing after the reinstall (with local server on), then take a look at the server.Your user library folder is hidden by default and can be accessed via: Discussion in Support started by liam1223, December 31, 2015. The default location is in your local library folder: /Users/YOURUSERNAME/Library/Application Support/Uber Entertainment/Planetary Annihilation ~/Library/Application Support/Uber Entertainment/Planetary Annihilation Forums > Planetary Annihilation Games > Planetary Annihilation: TITANS > Support > Planetary Annihilation News Guides Discord Community Rules & Guidelines. MacOS Planetary Annihilation Data Directory The vanilla version had long refused to even launch and this one possessed an incredibly odd bug wherin the camera panned perfectly smoothly and I experienced no loss of framerate, but everything happening in-game, unit movement and combat and the like, was so stuttered as to appear like a slide. ok I dont mind fighting hard AI heak in every strategy game I have i played the AI is hard but the AI in this game is way way too smart in 1 game the AI did a 3 way flack, beat me to the nexts plantary and kills me under 10 mins its like it know ever move I do. But once it happens once, I cannot mouse over. It does not always happen, often I can go an entire game without an issue. It is due to the 'preview' feature, so when I hover over a planet it crashes the game. MacOS is our primary development environment. I kickstarted Planetary Annihilation some years ago and until today I was unable to ever play it. Using the top right menu to swap between planets, it will sometimes randomly cause my game to crash completely. This font has a unique and eye-catching design that can capture a student’s attention in headings, titles, or posters. Dreaming Outloud Sans Aĭreaming Outloud Sans A is an approachable and friendly font with rounded edges and soft curves. Nunito also offers a range of weights and styles, including regular, bold, italic, and condensed variants. Nunito has a very polished and professional appearance, making this font an ideal choice for lesson plans, presentations, and other types of handouts. Nunito is a versatile and modern font that offers clarity and readability for your students. Its rounded letterforms can create a warm and inviting atmosphere in your educational materials. Schoolbell is child-friendly and approachable with a whimsical appearance, making it best suited for younger students. Schoolbell is a well-named font for teachers that acts as a highly readable yet slightly stylistic choice. Black Blones can be utilized in various ways, including posters, bulletin board displays, presentations, and slideshows. Black Bonesīlack Bones is a display font that works for teachers who are looking for a unique and appealing brush style option. League Spartan’s clean and well-defined letterforms are able to communicate your message clearly and effectively, which is crucial for any teacher. League Spartan is a bold font that’s best used when you need to grab your student’s attention. If you’re looking for a font that’s both functional and visually pleasing. This makes Lato an excellent choice for handouts, worksheets, and presentations. Lato is a versatile sans-serif font with clean and crisp legibility. Some of these fonts are only available for Canva Pro users, and these fonts will be mentioned as such. The following 35 fonts were chosen for various reasons, including legibility, engagement potential, and creative expression. I haven't slept in days because of what is going on round here, because my children are out of their routine because of this thudding of a ball and none to quietly either, which scares my 21 month old, but I am concerned now about repercussions the sooner i get out of here the better i can not contemplate how badly I want to get out of here. I was annoyed but i think i have a right to peace and quiet in my own home, I will not go round to her door to ask her to tell them because I'm scared i will get my head kicked in, Next thing i know she came knocking on my door and started shouting at me and swearing intimidating me and my 21 month old son, I tried to tell her i have already told them 3 times now and she kept butting in saying I am Fing talking do not interrupt me, you have a fing problem with my children kicking a ball about then you come to me, the way she said this was so intimidating I contemplated calling the police, How long do i have to put up with this mental torture in my own home? I was so angry today i called the housing association and explained that the situation is getting worse here and told them exactly what had happened the thing is, they didn't bother about the threat her friend made against me and my children before what is going to make them bother now. I went out again and i told them Off, my words were I have already told you once please stop kicking the ball at the wall because of damage and my son was scared. I told the neighbors children to please do not kick the ball at the outside wall soon after they literally started doing it again constantly but louder this time and scaring my 21 month old ds. “I’m pretty sure he won, because he got a really nice trophy,” Bobby Volkel said via SI.I have recently posted on here about another issue reguarding the same person and now this, Every day i have to constantly hear the thud thud thud of football on my outside wall going on until after 6 at night when my children are supposed to be sleeping, I cannot put my 21 month old down for a nap through the day or to sleep at an appropriate time as well as my daughter due to this constant thudding of a ball on my outside wall. Reid said at Super Bowl 54 media availability that he didn’t actually win the competition, but one of his childhood friends thinks he did. Reid: No, he was 8 - that kid’s 8 right there. they had to go into the Ram locker room and pull that jersey out, seriously. Gruden: That’s unbelievable! Did someone check IDs here? You’ve got a beard! That’s Monday Night Football right there. Jon Gruden: WHO IS THIS?! Tell me this video - look at Andrew Reid, that can’t be you.Īndy Reid: That’s me. When now- Raiders coach Jon Gruden was still with ESPN, he sat down with Reid to talk about the video: They ended up going into the Rams locker room and grabbing a jersey from Les Josephson, the Rams’ starting running back who was listed at 6’1, 207 pounds.Īs for the tiny dude behind Reid, he was only 8 years old. No really! Via Sports illustrated:īut when Reid arrived, organizers had to scramble to find him a jersey - none of the youth sizes came close to fitting. Reid was so large that he had to borrow an adult-sized Rams jersey from one of the players. The pass portion of the competition was aired on national TV at halftime. From there, he moved on to the next round, hosted at halftime of a Monday Night Football game between the Rams and Washington at the LA Coliseum. Reid, a native of Los Angeles, won his regional competition in 1971. The three were then combined for the player’s overall score. The contestants got one punt, pass, and kick attempt, and then received scores for each based on distance and accuracy. Held in various cities throughout the United States, players ages 5-16 were welcome to participate. It was a youth football competition run by the NFL from 1961-2017. What the heck was the Punt, Pass, and Kick competition? This photo is so fantastic it needs to be hung in a museum, if I do say so myself. 22’s dad, but notice how Reid’s last name is misspelled on the graphic. Not only does he literally looks like No. I need you all to look at this image once more, because it is just so damn good: The app also offers a unique feature: a “1-Click Report” template that lets you quickly fill out a detailed summary needed for an insurance claim, covering the place, time, impact, and video footage involved in the incident. These events are instantly saved to your phone, including GPS location tracking, and are also auto-backed up to the user's private Nexar cloud. This free app offers a lot of the perks you'd expect from a physical dash cam – as well as recording your drives, it even uses machine learning to automatically sense important driving events, such as hard brakes and even collisions. With a total of 500 million miles recorded behind the wheel, the Nexar dash cam app comes with a large fanbase – and for good reason. Read on to see all our dash cam reviews and advice. But for personal use only, a dash cam app can be a short term substitute or low budget alternative. It should be noted that compared to a dedicated dashboard camera, getting a dash cam app is not usually the best choice: reliability and convenience in particular will suffer. We've determined Nexar AI is the best dash cam app for iPhone – it offers great basic abilities, impressive machine learning-powered features, and an automated cloud backup that makes it easy to save your videos instantly.ĪutoBoy is the best dash cam app for Android – it includes granular settings, and reliably records even while running in the background of a phone. Our criteria centered around three main areas: how well the basic dash cam app features were executed what additional perks, if any, were included in the app and the quality of user feedback included in each app's reviews. We've combed through the top dash cam apps for iPhone and Android to determine which are the best. It will be easy to use, shoot high quality video, and offer a simple ways to export files, whether by USB, uploading to Google Drive or Dropbox, or automatically uploading to cloud storage. When we do, we shall ensure that the third party complies with all laws and regulations relating to the safe and fair storage and usage of the data that we provide to them.The best dash cam app will be able to loop record, use a collision detection sensor (called a G sensor), and use a phone's GPS ability to track location. We may occasionally share your non-confidential data with third parties to provide you with relevant offers that we feel may be of interest to you. We have no control over this and you should review the privacy policy of any advertiser that you visit as a result of an advert or link on this website. Our advertisers may also use cookies on their website. You can easily decline or remove cookies from your computer using the settings within the Internet Options section in your computer control panel. All computers have the ability to decline cookies. Cookies contain information that is transferred to your computer's hard drive and then stored there and transferred to us where appropriate to help us to improve our website and the service that we provide to you. This cookie file is stored on the hard drive of your computer. Where used, these cookies are downloaded to your computer automatically. We may also use the cookies to gather information about your general internet use to further assist us in developing or website. Pease note that no personally identifiable information is recorded. When collected this information is used by us to improve our website and further enhance the visitor experience and, may be shared with advertisers. We may sometimes use cookies on this website to record aggregate statistical information about the visitors to our site and the use that our visitors make of the website. We may occasionally use your email address to send you website announcements regarding changes to our website, including improvements, and service or product changes that may affect our website.Ĭookies are sometimes used to improve the website experience of a visitor to a website. You can choose a preferred tool based on your preference. This post introduces some professional disk cleanup software for Mac or Windows 10/11 to help you clean disk space on your computer. It includes a driver updater, PC health check app, software updater, cleanup tool, system monitor, etc.ĬleanMyPC is a professional PC cleaning software program that helps you clean up junk files, speed up your PC, and improve your PC’s performance. It helps you optimize your computer performance, speed up your Windows computer, and maintain your online privacy. It aims to make your computer run faster.ĬCleaner is a professional hard drive cleaner for Windows 11/10. It helps you clean junk from browsers, remove junk data in the Windows system, and defragment your disk. Wise Disk Cleaner is a free disk cleanup and defragment tool for Windows. Select the files you want to delete and click OK to scan and delete them.Select the drive you want to clean and click OK.You can press Windows + R, type cleanmgr.exe, and press Enter to easily launch Disk Cleanup on your Windows 10/11 PC.You can use it to scan and remove downloaded program files, temporary Windows or Internet files, Recycle Bin files, and more. It is designed to free up disk space on Windows’s hard drive. Windows computer comes with a built-in disk cleanup tool named Disk Cleanup. With over 511,000 downloads, more than 12,000 daily users use BuhoCleaner to optimize their Mac devices for maximum performance. Top Disk Cleanup Software for Windows 10/11 BuhoCleaner is a Mac cleaner that boosts the device’s performance by freeing up disk space. You can use it to clean up your Mac, analyze disk space usage, uninstall apps completely, manage background apps, clear cache, find and remove duplicates, and more. This disk cleanup software for Mac bundles six cleanup tools. It also includes a malware removal tool and some other system optimization features. It helps you clean up system junk, remove large files, uninstall apps, and more. Just choose according to your needs.CleanMyMac X is also a comprehensive Mac disk cleanup and optimization tool. I also appreciate that the program has a straightforward design. Besides, it perfectly copes with cleaning up old files and detecting bulky elements that hamper your system’s smooth operation. No memory usage monitoring in the menu barĪs you can see, all of these tools have pros and cons, and it's hard to say which one is the best. Verdict: I like that BuhoCleaner can easily remove junk files on Mac devices, which means, they will work faster.With this tool, you can free up memory on your Mac by identifying and closing memory-hogging apps and processes. MacKeeper is known as a Mac cleaner, but it also comes with memory cleaning feature. BuhoCleaner Business Plan (lifetime/10 Macs): 71.99 37. Lists apps with significant memory usage.Unlike other memory cleaners, Memory Diag gives you more freedom to customize its apperance and menu bar icon. It helps you keep an eye on your memory usage and allows you to recycle memory manually or automatically. Requires payment to use the Disk Usage panelĪnother tool you can try is Memory Diag.What makes this tool special is that it can automatically release memory. It can display your memory usage in the menu bar, and show the detailed memory information, such as which apps are eating up your memory space. This memory cleaner is developed by Nektony. Also, it will show you inactive apps which you can close to free up more memory space. And if you click on its icon, you can easily see which apps are using the most memory space. It shows how much memory space available in the menu bar. Memory Clean 3 is a simple and lightweight memory cleaner. Features: Speed Up and Boost Mac Performance - Feel your Mac running slow BuhoCleaner can terminate these unresponsive windows and reduce slow loading time. Only allows deletion of files up to 3GB for free.System status monitoring in the menu bar. Rename filenames as needed, preceded with track numbers, right caps, right accents, umlauts etc, using NIYW or Bulk Rename Utility. So, every time I buy an album or several, and rip them, I follow the same process. I am probably just weird, but the end result, especially when seem on the pretty Evo front panel, or on a variety of media players, is good. The tags all needed to be the same ID3 version and APE tags for MP3Gain for me, as I run multiple media players, and multiple DLNA renderers and servers, and you end up with inconsistencies if you don't have a process that always works for all players. I ended up having to go back and correct! I also wanted embedded cover art to be the same X x Y pixels and of similar visual quality as a JPGs. This kind of ruled out the automated (set and forget), batch cover downloads for me as covers vary a lot (e.g, US release vs UK release, remix versions etc). I am OCD about consistency of which tags I used, and for the covers, I wanted to match all the physical CD inserts and vinyl sleeves. I've tried various tag+artwork mechanisms since such things existed, and have ended up with >60K files, most are MP3, but all the good stuff stuff as FLACs. Just saying, as this had me puzzled for several days when I could not see why no cover art was displayed in some of my systems! Sometimes only a true jpg will be displayed - but you can scan your (separate) cover art files in your folders using a program like trid.exe ( ) which can id and batch convert to jpg, and then you can batch include the art using MP3tag. You can adjust all art in the files to be consistently sized, say 220x220 is good enough without using much storage space.Īnother common thing, is that sometimes covers never display, embedded or as separate file - there is a lot of cover art you can download that appears as a jpg file but sometimes is a different format, like png. If you want the best chance of a renderer being able to show cover art, embed the art (as front cover) into the files using MP3tag in conjunction with AlbumArtDownloader. I just tested this with two different DLNA servers. That may be true for mconnect, (also for my Evo streamer) but not for say, FB2K, VLC and others. Each model includes full protection by providing a great warranty as well as lifetime phone support. The most popular are the Pop-up TV Lift systems whereby the TV Lifts and TV's are remotely brought up into the viewing area and lowered when not in use. There are two types of TV Lift Mechanisms: Pop-up TV Lifts, and Drop-Down TV Lifts. Vincent & Grenadines (USD $) Sudan (USD $) Suriname (USD $) Svalbard & Jan Mayen (USD $) Sweden (USD $) Switzerland (USD $) Taiwan (USD $) Tajikistan (USD $) Tanzania (USD $) Thailand (USD $) Timor-Leste (USD $) Togo (USD $) Tokelau (USD $) Tonga (USD $) Trinidad & Tobago (USD $) Tristan da Cunha (USD $) Tunisia (USD $) Turkey (USD $) Turkmenistan (USD $) Turks & Caicos Islands (USD $) Tuvalu (USD $) U.S.Pop up, Drop Down or Flip Down MechanismsįIRGELLI TV Lifts offer superior electro-mechanical technology with extra quiet and smooth operation. 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Update konten reguler dengan lebih banyak free movie, senjata, gore dan aksi yang tiada henti.Mencapai puncak klasemen permainan dengan bersaing bersama teman anda.Pertarungan yang lucu, dan pakaian yang aneh.Mendapat upah pertempuran dari 20 film yang berbeda dan 10 mode permainan yang unik.Gaya kartun yang terinspirasi oleh setelan hollywood.Merebus dan membakar para zombie dengan senjata yang gahar dan ganas.Bertahan dan membasmi para zombie yang datang bergerombol.Menerjang, berlari dan membantai di aksi shooting dual stik. Tugas anda disini yaitu untuk membasmi para zombie yang berkeliaran di kota tersebut, jangan sampai anda lengah atau anda akan digigit dan berubah menjadi zombie seperti mereka. Sehingga, kota tersebut penuh dengan para zombie. Para zombie ini tidak hanya mengobrak-abrik kota, namun mereka menyabarkan virus zombie kepada masyarakat los angeles. Game ini bercerita tentang keadaan kota los angeles yang diserang oleh gerombolan zombie, jalan-jalan yang tadinya ramai dan kota yang tadinya mewah kini menjadi menyeramkan dan berbahaya. Zombiewood - Zombie in L.A! ~ Merupakan sebuah game aksi yang dirilis oleh developer game Gameloft, game ini mempunyai kualitas grafik yang halus dan gameplay menarik yang menegangkan. |
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